Despite age-related changes in skin appearance are well documented, less is known about changes of the skin barrier function during aging. Several markers of skin barrier function such as transepidermal water loss, stratum corneum hydration, sebum secretion and pH value were used to reveal these changes, but the influence aging on skin barrier function is still controversial. Some studies present an impairment of the skin barrier function with aging, while others show no significant changes. In this review, we discuss an age-related alteration and associating factors of barrier function.
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